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And not in an undignified "cut short in the middle of the story" way. It's when the creator decides to definitively close the series forever, sometimes leaving no outlet for any follow-ups or expanded universe. It's strange that the biggest sign that creators care about their story is that they're willing to let go. In a world of media series that go on indefinitely, often turning into franchise zombies along the way, it's almost surreal for a series to have a dignified end.
But maybe indefinitely running series are just a trait of North American media, considering British Brevity. Then again, many of the major video game franchises are Japanese, and Britain has Doctor Who and Coronation Street, so maybe the long runners are just the ones that remain in the public consciousness longer.
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Like, something like Doctor Who is very episodic to begin with, and there's no real overarcing story. It's less likely to overstay it's welcome with fans. It works as something that runs indefinitely.
But something like Lost, where there is a very important myth arc, works much better as something that has an end. Some stories need endings. Some stories can't sustain themselves forever.
If any of that made any sense.